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Carotid Intraplaque Haemorrhage: Pathogenesis, Histological Classification, Imaging Methods and Clinical Value by Mura, Mathilde; Della Schiava, Nellie; Long, Anne; Chirico, Erica N.; Pialoux, Vincent; Millon, Antoine is a Medicine article available to read on EtoBox.

What is Carotid Intraplaque Haemorrhage: Pathogenesis, Histological Classification, Imaging Methods and Clinical Value about?

Vulnerable carotid atherosclerotic plaques are characterised by several risk factors, such as inflammation, neovascularization and intraplaque haemorrhage (IPH). Vulnerable plaques can lead to ischemic events such as stroke. Many studies reported a relationship between IPH, plaque rupture, and ischemic stroke. Histology is the gold standard to evaluate IPH, but it required carotid endarterectomy (CEA) surgery to collect the tissue sample. In this context, several imaging methods can be used as a non-invasive way to evaluate plaque vulnerability and detect IPH. Most imaging studies showed that IPH is associated with plaque vulnerability and stroke, with magnetic resonance imaging (MRI) being the most sensitive and specific to detect IPH as a predictor of ischemic events. These conclusions are however still debated because of the limited number of patients included in these studies; further studies are required to better assess risks associated with different IPH stages. Moreover, IPH is implicated in plaque vulnerability with other risk factors which need to be considered to predict ischemic risk. In addition, MRI sequences standardization is required to compare results from differe

Who reads Carotid Intraplaque Haemorrhage: Pathogenesis, Histological Classification, Imaging Methods and Clinical Value?

Author

Mura, Mathilde; Della Schiava, Nellie; Long, Anne; Chirico, Erica N.; Pialoux, Vincent; Millon, Antoine

Publisher

AME Publishing Company; [Hong Kong]: AME Publishing Company (ISSN 2305-5839)

Published

2020

Language

EN

Field

Medicine (Health Sciences)