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Can I read Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons on EtoBox?
Impact and relationship of anterior commissure and time-dose factor on the local control of T1N0 glottic cancer treated by 6 MV photons by Chi-Chung Tong; Kwok-Hung Au; Roger KC Ngan; Sin-Ming Chow; Foon-Yiu Cheung; Yiu-Tung Fu; Joseph SK Au; Stephen CK Law is a Medicine article available to read on EtoBox.
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## Background To evaluate prognostic factors that may influence local control (LC) of T1N0 glottic cancer treated by primary radiotherapy (RT) with 6 MV photons. ## Methods We retrospectively reviewed the medical records of 433 consecutive patients with T1N0 glottic cancer treated between 1983 and 2005 by RT in our institution. All patients were treated with 6 MV photons. One hundred and seventy seven (41%) patients received 52.5 Gy in 23 fractions with 2.5 Gy/fraction, and 256 (59%) patients received 66 Gy in 33 fractions with 2 Gy/fraction. ## Results The median follow-up time was 10.5 years. The 10-year LC rates were 91% and 87% for T1a and T1b respectively. Multivariate analysis showed LC rate was adversely affected by poorly differentiated histology (Hazard Ratio [HR]: 7.5, __p__ = 0.035); involvement of anterior commissure (HR: 2.34, __p__ = 0.011); fraction size of 2.0 Gy (HR: 2.17, __p__ = 0.035) and tumor biologically effective dose (BED) 2.0 Gy. We recommend that fraction size > 2.0 Gy should be utilized, for radiation schedules with five daily fractions each week.
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- Author
- Chi-Chung Tong; Kwok-Hung Au; Roger KC Ngan; Sin-Ming Chow; Foon-Yiu Cheung; Yiu-Tung Fu; Joseph SK Au; Stephen CK Law
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1748-717X)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)