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Can I read Topiramate: Efficacy and Tolerability in Children According to Epilepsy Syndromes on EtoBox?
Topiramate: Efficacy and Tolerability in Children According to Epilepsy Syndromes by Yann Mikaeloff; Anne de Saint-Martin; Josette Mancini; Sylviane Peudenier; Jean-Michel Pedespan; Louis Vallée; Jacques Motte; Marie Bourgeois; Alexis Arzimanoglou; Olivier Dulac; Catherine Chiron is a Medicine article available to read on EtoBox.
What is Topiramate: Efficacy and Tolerability in Children According to Epilepsy Syndromes about?
To evaluate the efficacy and tolerability of topiramate (TPM) as add-on therapy in children less than 12 years of age with refractory epilepsy, according to epilepsy syndromes, we conducted an open, prospective, pragmatic and multicenter study in France. Efficacy was assessed, especially according to epilepsy syndromes, as well as tolerability. We included 207 children (41 of whom were less than 4 years of age). TPM was effective (responders with >50% decrease in seizure frequency) in 50% of 128 patients with partial epilepsy, and in 44% of 79 patients with generalized epilepsy. In case of generalized epilepsy, responders more frequently had generalized symptomatic epilepsy, severe myoclonic epilepsy and myoclono-astatic epilepsy, whereas response rate was mild in both infantile spasms and Lennox-Gastaut syndrome (LGS). Improvement was well maintained in all patients during the treatment period (median 5.6 months). Seizure frequency/severity increased (worsening) in 13% of patients with partial epilepsy and 17% with generalized epilepsy (particularly in those with infantile spasms), and resulted in withdrawal of TPM for 8%. The most frequently reported adverse events were moderate
Who reads Topiramate: Efficacy and Tolerability in Children According to Epilepsy Syndromes?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yann Mikaeloff; Anne de Saint-Martin; Josette Mancini; Sylviane Peudenier; Jean-Michel Pedespan; Louis Vallée; Jacques Motte; Marie Bourgeois; Alexis Arzimanoglou; Olivier Dulac; Catherine Chiron
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)