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Therapeutic Potential Evaluation of Silk Sericin Stabilized Fisetin to Ulcerative Colitis by Chunru Wang; Yingjie Xiang; Wenjie Ma; Chuanlong Guo; Xiaochen Wu is a Materials Science article available to read on EtoBox.

What is Therapeutic Potential Evaluation of Silk Sericin Stabilized Fisetin to Ulcerative Colitis about?

## Abstract Ulcerative colitis is a chronic inflammatory bowel disease with a high recurrence rate. Natural phytochemical compounds are increasingly being considered as preventative and supportive treatments for this condition. However, the poor water solubility and stability of many of these compounds limit their effectiveness in vivo. To address this issue, fisetin (FT), a natural phytochemical with poor solubility, is stabilized using silk sericin (SS) to create a composite (SS/FT). The therapeutic potential of the SS/FT on ulcerative colitis is extensively investigated, and the results showed that it effectively alleviated the body weight loss and colon length shortening induced by dextran sulfate sodium. Notably, SS/FT downregulated the immune response, decreased colonic histopathological lesions, and reduced the cGAS/STING signal activation. This suggests that SS/FT may offer a promising therapy for treating ulcerative colitis.

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Author

Chunru Wang; Yingjie Xiang; Wenjie Ma; Chuanlong Guo; Xiaochen Wu

Publisher

Wiley

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)