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Clinical Presentation, Treatment, and Outcome of Parathyroid Carcinoma: Results of the NEKAR Retrospective International Multicenter Study by Christina Lenschow; Sina Schrägle; Stefan Kircher; Kerstin Lorenz; Andreas Machens; Henning Dralle; Philipp Riss; Christian Scheuba; Andreas Pfestroff; Christine Spitzweg; Andreas Zielke; Anna Nießen; Cornelia Dotzenrath; Burkhard Riemann; Marcus Quinkler; Christian Vorländer; Alexandra Zahn; Friedhelm Raue; Costanza Chiapponi; Karl Alexander Iwen; Thomas Steinmüller; Matthias Kroiss; Nicolas Schlegel is a Medicine article available to read on EtoBox.

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## Objective: In this retrospective cohort study, we describe the clinical presentation and workup of parathyroid carcinoma (pc) and determine its clinical prognostic parameters. primary outcome was recurrence free survival. ## Summary background data: Pc is an orphan malignancy for which diagnostic workup and treatment is not established. ## Methods: Eighty-three patients were diagnosed with pc between 1986 and 2018. disease-specific and recurrence-free survivals were estimated with the kaplan-meier method. risk factors for recurrence were identified by binary logistic regression with adjustment for age and sex. thirty-nine tumors underwent central histopathological review. ## Results: Renal (39.8%), gastrointestinal (24.1%), bone (22.9%), and psychiatric (19.3%) symptoms were the most common symptoms. surgical treatment was heterogeneous [parathyroidectomy [ptx)] alone: 22.9%; ptx and hemithyroidectomy: 24.1%; en bloc resection 15.7%; others 37.3%] and complications of surgery were frequent (recurrent laryngeal nerve palsy 25.3%; hypoparathyroidism 6%). recurrence of pc was observed in 32 of 83 cases. in univariate analysis, rate of recurrence was reduced when extended initial su

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Author

Christina Lenschow; Sina Schrägle; Stefan Kircher; Kerstin Lorenz; Andreas Machens; Henning Dralle; Philipp Riss; Christian Scheuba; Andreas Pfestroff; Christine Spitzweg; Andreas Zielke; Anna Nießen; Cornelia Dotzenrath; Burkhard Riemann; Marcus Quinkler; Christian Vorländer; Alexandra Zahn; Friedhelm Raue; Costanza Chiapponi; Karl Alexander Iwen; Thomas Steinmüller; Matthias Kroiss; Nicolas Schlegel

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)