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The dicationic derivatives of DBTAA: Interactions with DNA/RNA and antiproliferative effects on human cell lines by Marijana Radić Stojković; Ivo Piantanida; Marijeta Kralj; Marko Marjanović; Mladen Žinić; Dariusz Pawlica; Julita Eilmes is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Three dibenzotetraaza [14]annulenes non-covalently interacted with double-stranded DNA and RNA by mixed minor groove and/or intercalative binding mode. Observed interactions were strongly dependent on the steric exposure of positive charges and the length of the linkers of studied compounds as well as on the secondary structure and basepair composition of DNA/RNA. Compound 2 showed pronounced selectivity toward dA-dT-rich sequences and binding mode switch from dominant minor groove binding to ds-DNA to dominant intercalation into ds-RNA. Antiproliferative effect of studied compounds on human tumor and normal cell lines was in good agreement with the strength of observed interactions with DNA/RNA.

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Author

Marijana Radić Stojković; Ivo Piantanida; Marijeta Kralj; Marko Marjanović; Mladen Žinić; Dariusz Pawlica; Julita Eilmes

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)