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Can I read Tryptamine and Homotryptamine-based Sulfonamides as Potent and Selective Inhibitors of 15-Lipoxygenase on EtoBox?
Tryptamine and Homotryptamine-based Sulfonamides as Potent and Selective Inhibitors of 15-Lipoxygenase by David S. Weinstein; Wen Liu; Zhengxiang Gu; Charles Langevine; Khehyong Ngu; Leena Fadnis; Donald W. Combs; Doree Sitkoff; Saleem Ahmad; Shaobin Zhuang; Xing Chen; Feng-Lai Wang; Deborah A. Loughney; Karnail S. Atwal; Robert Zahler; John E. Macor; Cort S. Madsen; Natesan Murugesan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tryptamine and Homotryptamine-based Sulfonamides as Potent and Selective Inhibitors of 15-Lipoxygenase about?
A series of inhibitors of mammalian 15-lipoxygenase based on tryptamine and homotryptamine scaffolds is described. Compounds with aryl substituents at C-2 of the indole core of tryptamine and homotryptamine sulfonamides (e.g., 37a-p) proved to be potent inhibitors of the isolated enzyme. Selected compounds also demonstrated desirable inhibition selectivities over isozymes 5-and P-12-LO.
Who reads Tryptamine and Homotryptamine-based Sulfonamides as Potent and Selective Inhibitors of 15-Lipoxygenase?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- David S. Weinstein; Wen Liu; Zhengxiang Gu; Charles Langevine; Khehyong Ngu; Leena Fadnis; Donald W. Combs; Doree Sitkoff; Saleem Ahmad; Shaobin Zhuang; Xing Chen; Feng-Lai Wang; Deborah A. Loughney; Karnail S. Atwal; Robert Zahler; John E. Macor; Cort S. Madsen; Natesan Murugesan
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)