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Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities by Anne M. Fitzpatrick; Dean P. Jones; Lou Ann S. Brown is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities about?

Asthma is a chronic inflammatory disorder of the airways associated with airway hyper-responsiveness and airflow limitation in response to specific triggers. Whereas inflammation is important for tissue regeneration and wound healing, the profound and sustained inflammatory response associated with asthma may result in airway remodeling that involves smooth muscle hypertrophy, epithelial goblet-cell hyperplasia, and permanent deposition of airway extracellular matrix proteins. Although the specific mechanisms responsible for asthma are still being unraveled, free radicals such as reactive oxygen species and reactive nitrogen species are important mediators of airway tissue damage that are increased in subjects with asthma. There is also a growing body of literature implicating disturbances in oxidation/reduction (redox) reactions and impaired antioxidant defenses as a risk factor for asthma development and asthma severity. Ultimately, these redox-related perturbations result in a vicious cycle of airway inflammation and injury that is not always amenable to current asthma therapy, particularly in cases of severe asthma. This review will discuss disruptions of redox signaling and co

Who reads Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities?

Author

Anne M. Fitzpatrick; Dean P. Jones; Lou Ann S. Brown

Publisher

Mary Ann Liebert Inc

Published

2012

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)