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New Milliliter-scale Stirred Tank Bioreactors for the Cultivation of Mycelium Forming Microorganisms by Ralf Hortsch; Ansgar Stratmann; Dirk Weuster-Botz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract A novel milliliter‐scale stirred tank bioreactor was developed for the cultivation of mycelium forming microorganisms on a 10 milliliter‐scale. A newly designed one‐sided paddle impeller is driven magnetically and rotates freely on an axis in an unbaffled reaction vessel made of polystyrene. A rotating lamella is formed which spreads out along the reactor wall. Thus an enhanced surface‐to‐volume ratio of the liquid phase is generated where oxygen is introduced via surface aeration. Volumetric oxygen transfer coefficients (__k__~L~__a__) > 0.15 s^−1^ were measured. The fast moving liquid lamella efficiently prevents wall growth and foaming. Mean power consumption and maximum local energy dissipation were measured as function of operating conditions in the milliliter‐scale stirred tank bioreactor (__V__ = 10 mL) and compared to a standard laboratory‐scale stirred tank bioreactor with six‐bladed Rushton turbines (__V__ = 2,000 mL). Mean power consumption increases with increasing impeller speed and shows the same characteristics and values on both scales. The maximum local energy dissipation of the milliliter‐scale stirred tank bioreactor was reduced compared to the labora

Who reads New Milliliter-scale Stirred Tank Bioreactors for the Cultivation of Mycelium Forming Microorganisms?

Author

Ralf Hortsch; Ansgar Stratmann; Dirk Weuster-Botz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)