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The amyloid proteins of Alzheimer's disease as potential targets for drug therapy by Claudia B. Caputo; Andre I. Salama is a Medicine article available to read on EtoBox.
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The amyloid proteins of Alzheimer's disease as potential targets for drug therapy. NEUROBIOL AGING 10(5) 451461, 1989.--Two amyloid proteins accumulate in Alzheimer's disease. These proteins, beta amyloid protein and paired helical filament protein, are present in the hallmark lesions of Alzheimer's disease, neuritic plaques and neurofibrillary tangles. Although the amino acid sequences of these two proteins are likely to be different, they nevertheless share certain physical characteristics which define each as belonging to a common class of proteins, amyloid proteins. Since these proteins are probably important in the pathology of Alzheimer's disease, drugs that prevent their accumulation should have therapeutic utility. Based on the amyloidoses associated with other diseases, three mechanisms for amyloid formation have emerged. These mechanisms form a framework for studying Alzheimer amyloids and designing interventions. One mechanism involves posttranslational events which render a normal protein amyloidogenic. Proteolysis, phosphorylatiom glycosylation, and transglutamination may be relevant posttranslational events in Alzheimer's disease. If more conclusive evidence can be ge
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- Author
- Claudia B. Caputo; Andre I. Salama
- Published
- 1989
- Language
- EN
- Field
- Medicine (Health Sciences)