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Meta-Analytic Operation of Threshold-independent Filtering (MOTiF) Reveals Sub-threshold Genomic Robustness in Trisomy by Siegelmann, Roy; Siegelmann, Hava is a scholarly article available to read on EtoBox.

What is Meta-Analytic Operation of Threshold-independent Filtering (MOTiF) Reveals Sub-threshold Genomic Robustness in Trisomy about?

Trisomy, a form of aneuploidy wherein the cell possesses an additional copy of a specific chromosome, exhibits a high correlation with cancer. Studies from across different hosts, cell-lines, and labs into the cellular effects induced by aneuploidy have conflicted, ranging from small, chaotic global changes to large instances of either overexpression or underexpression throughout the trisomic chromosome. We ascertained that conflicting findings may be correct but miss the overarching ground truth due to careless use of thresholds. To correct this deficiency, we introduce the Meta-analytic Operation of Threshold-independent Filtering (MOTiF) method, which begins by providing a panoramic view of all thresholds, transforms the data to eliminate the effects accounted for by known mechanisms, and then reconstructs an explanation of the mechanisms that underly the difference between the baseline and the uncharacterized effects observed. As a proof of concept, we applied MOTiF to human colonic epithelial cells, discovering a uniform decrease in gene expression levels throughout the genome, which while significant, is beneath most common thresholds. Using Hi-C data we identified the struct

Author

Siegelmann, Roy; Siegelmann, Hava

Published

2023

Language

EN