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Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection by Eli Maymon; Roberto Romero; Gaurav Bhatti; Piya Chaemsaithong; Nardhy Gomez-Lopez; Bogdan Panaitescu; Noppadol Chaiyasit; Percy Pacora; Zhong Dong; Sonia S. Hassan; Offer Erez is a Medicine article available to read on EtoBox.

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## Abstract ## Objective: The objective of this study is to determine whether the amniotic fluid (AF) concentration of soluble CXCR3 and its ligands CXCL9 and CXCL10 changes in patients whose placentas show evidence of chronic chorioamnionitis or other placental lesions consistent with maternal anti-fetal rejection. ## Methods: This retrospective case-control study included 425 women with (1) preterm delivery (n=92); (2) term in labor (n=68); and (3) term not in labor (n=265). Amniotic fluid CXCR3, CXCL9 and CXCL10 concentrations were determined by ELISA. ## Results: (1) Amniotic fluid concentrations of CXCR3 and its ligands CXCL9 and CXCL10 are higher in patients with preterm labor and maternal anti-fetal rejection lesions than in those without these lesions [CXCR3: preterm labor and delivery with maternal anti-fetal rejection placental lesions (median, 17.24 ng/mL; IQR, 6.79–26.68) vs. preterm labor and delivery without these placental lesions (median 8.79 ng/mL; IQR, 4.98–14.7; P=0.028)]; (2) patients with preterm labor and chronic chorioamnionitis had higher AF concentrations of CXCL9 and CXCL10, but not CXCR3, than those without this lesion [CXCR3: preterm labor with chronic c

Who reads Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection?

Author

Eli Maymon; Roberto Romero; Gaurav Bhatti; Piya Chaemsaithong; Nardhy Gomez-Lopez; Bogdan Panaitescu; Noppadol Chaiyasit; Percy Pacora; Zhong Dong; Sonia S. Hassan; Offer Erez

Publisher

Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 0300-5577)

Published

2017

Language

EN

Field

Medicine (Health Sciences)