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Pharmacokinetics of Ketotiffn After Oral Administration to Healthy Male Subjects by Dr A. Grahnén; A. Lönnebo; O. Beck; S-Å Eckernäs; B. Dahlström; B. Lindström is a Medicine article available to read on EtoBox.

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## Abstract The pharmacokinetics of 2 mg ketotifen from four different oral dosage forms were examined in two randomized, balanced cross‐over studies. Forty healthy male subjects participated. Each of 20 subjects received two capsule formulations and each of the other 20 subjects received two syrup formulations. Ketotifen concentrations in plasma were determined by a modified GC—MS method. The limit of quantitation was 40 pg ml^−1^. Inter‐day precision and accuracy calculated from quality control samples were 16·3 per cent (−1·9 per cent), 19·8 per cent (+4·5 per cent) and 23·6 per cent (+ 5·9 per cent) at plasma concentration levels of 86 (__n__ = 18), 215 (__n__ = 19) and 343 (__n__ = 18) pg ml^−1^, respectively. Ketotifen was rapidly absorbed from all dosage forms reaching __C__~max~ in the order of 400 pg ml^−1^ after the syrup formulations and 300 pg ml^−1^ after the capsule formulations within 2 to 4 h. The syrup formulations showed a significantly more rapid rate of absorption as assessed by __T__~max~. No significant differences in extent of absorption between dosage forms were observed. The terminal elimination half‐life of ketotifen varied between subjects from 7 to 27 ho

Who reads Pharmacokinetics of Ketotiffn After Oral Administration to Healthy Male Subjects?

Author

Dr A. Grahnén; A. Lönnebo; O. Beck; S-Å Eckernäs; B. Dahlström; B. Lindström

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0142-2782)

Published

1992

Language

EN

ISBN

9782510130408

Field

Medicine (Health Sciences)