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Paper 1 by Sofía Ignacia Utreras Olivares is a document available to read on EtoBox.

This study investigates the pharmacology of Orexin Receptor 2 (OX2R) using BRET techniques, revealing ligand-dependent spatio-temporal dynamics in G protein signaling. Upon stimulation with Orexin-A and Orexin-B, distinct kinetic effects and robust trafficking of G proteins were observed, particularly highlighting the role of β-arrestin2 in complex formation. These findings suggest a need for further research into the physiological implications of OX2R

Author

Sofía Ignacia Utreras Olivares

Language

EN