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Clonal Analysis of Cutaneous Fibrous Histiocytoma (Dermatofibroma) by Pei Hui; Earl J. Glusac; John H. Sinard; Archibald S. Perkins is a Medicine article available to read on EtoBox.

What is Clonal Analysis of Cutaneous Fibrous Histiocytoma (Dermatofibroma) about?

**Background:** Dermatofibroma (DF) or cutaneous fibrous histiocytoma is a common benign fibrohistiocytic lesion involving the dermis and subcutis. Histologically, it is subclassified into fibroblastic and histiocytoid forms. Its histogenesis is controversial. While often referred to as a neoplastic process, definite evidence of neoplasia in DF has been lacking. Alternatively, some authorities have suggested that DF is a fibrosing inflammatory process. Diagnostically, the most important question faced is the distinction from dermatofibrosarcoma protuberans (DFSP). Misdiagnosis can occur, as the early phase of DFSP can simulate DF, particularly the deep and cellular forms of DF. **Methods:** To address this issue, and to investigate whether DF is in fact a neoplasm, we evaluated 31 examples of DF of various histological types in female patients and assessed clonality by analyzing X‐chromosome inactivation as indicated by the methylation status of the androgen receptor gene (HUMARA). Representative cases of DFSP were analyzed for comparison. **Results:** Among the selected 31 cases of DF, 24 cases provided intact DNA and informative polymorphism at the AR alleles, including one case

Who reads Clonal Analysis of Cutaneous Fibrous Histiocytoma (Dermatofibroma)?

Author

Pei Hui; Earl J. Glusac; John H. Sinard; Archibald S. Perkins

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6987)

Published

2002

Language

EN

Field

Medicine (Health Sciences)