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Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region by Eric Shink; Mario Harvey; Monique Tremblay; Bernard Gagné; Pascal Belleau; Catherine Raymond; Michel Labbé; Marie‐Pierre Dubé; Ronald G. Lafrenière; Nicholas Barden is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Previous results from our genetic analyses using pedigrees from a French Canadian population suggested that the interval delimited by markers D12S86 and D12S378 on chromosome 12 was the most probable genomic region to contain a susceptibility gene for affective disorders. Here we present a more detailed genetic analysis of a 7.7 Mb genomic region located on 12q24.31. This region was saturated with 20 microsatellite markers to refine the candidate region and linkage analysis performed in 41 families from the Saguenay‐Lac‐St‐Jean (SLSJ) region of Quebec. The results of two point parametric analysis using MFLINK supported the presence of a susceptibility locus on chromosome 12q24.31. Association studies with microsatellite markers using a case/control sample from the same population (n = 401) and analyzed with CLUMP revealed significant allelic associations between the bipolar phenotype and markers NBG6 (__P__ = 0.008) and NBG12 (__P__ < 10^−3^). According to these results, we investigated candidate genes in the NBG12 area. We analyzed 32 genes for the presence of polymorphisms in coding sequences and intron/exon junctions and genotyped 22 non‐synonymous SNPs in the SLSJ c
Who reads Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Eric Shink; Mario Harvey; Monique Tremblay; Bernard Gagné; Pascal Belleau; Catherine Raymond; Michel Labbé; Marie‐Pierre Dubé; Ronald G. Lafrenière; Nicholas Barden
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1552-4841)
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)