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Hepatitis C virus infection in haemodialysis and kidney transplant patients by Seema Baid-Agrawal; Manuel Pascual; Darius Moradpour; Ulrich Frei; Nina Tolkoff-Rubin is a Medicine article available to read on EtoBox.

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## Abstract Chronic infection with hepatitis C virus (HCV) is an important global health problem. The prevalence of HCV is significantly higher in haemodialysis and kidney transplant patients, as compared to the general population. In spite of the relatively milder liver disease activity reported in HCV‐infected haemodialysis patients, HCV infection adversely affects survival. Likewise, HCV has a detrimental effect on both patient and graft survival after kidney transplantation. However, patient survival is significantly better with kidney transplantation compared to remaining on dialysis; therefore, HCV infection alone should not be a contraindication to transplantation. Combination antiviral therapy with pegylated interferon‐alpha and low‐dose ribavirin is currently evolving in haemodialysis patients. Interferon‐alpha (standard/pegylated) is relatively contraindicated after kidney transplantation because of an increased risk of allograft rejection. Therefore, antiviral treatment of transplant candidates while on dialysis remains the best option and may avoid the risk of HCV‐associated liver and renal disease after transplantation. Large multi‐centre clinical trials are required i

Who reads Hepatitis C virus infection in haemodialysis and kidney transplant patients?

Author

Seema Baid-Agrawal; Manuel Pascual; Darius Moradpour; Ulrich Frei; Nina Tolkoff-Rubin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1052-9276)

Published

2007

Language

EN

Field

Medicine (Health Sciences)