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Comparing Myelin-sensitive Magnetic Resonance Imaging Measures and Resulting G-ratios in Healthy and Multiple Sclerosis Brains by Ronja C. Berg; Aurore Menegaux; Thomas Amthor; Guillaume Gilbert; Maria Mora; Sarah Schlaeger; Viola Pongratz; Markus Lauerer; Christian Sorg; Mariya Doneva; Irene Vavasour; Mark Mühlau; Christine Preibisch is a Neuroscience article available to read on EtoBox.
What is Comparing Myelin-sensitive Magnetic Resonance Imaging Measures and Resulting G-ratios in Healthy and Multiple Sclerosis Brains about?
The myelin concentration and the degree of myelination of nerve fibers can provide valuable information on the integrity of human brain tissue. Magnetic resonance imaging (MRI) of myelin-sensitive parameters can help to non-invasively evaluate demyelinating diseases such as multiple sclerosis (MS). Several different myelin-sensitive MRI methods have been proposed to determine measures of the degree of myelination, in particular the g-ratio. However, variability in underlying physical principles and different biological models influence measured myelin concentrations, and consequently g-ratio values. We therefore investigated similarities and differences between five different myelin-sensitive MRI measures and their effects on g-ratio mapping in the brains of both MS patients and healthy volunteers. We compared two different estimates of the myelin water fraction (MWF) as well as the inhomogeneous magnetization transfer ratio (ihMTR), magnetization transfer saturation (MTsat), and macromolecular tissue volume (MTV) in 13 patients with MS and 14 healthy controls. In combination with diffusion-weighted imaging, we derived g-ratio parameter maps for each of the five different myelin me
Who reads Comparing Myelin-sensitive Magnetic Resonance Imaging Measures and Resulting G-ratios in Healthy and Multiple Sclerosis Brains?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Ronja C. Berg; Aurore Menegaux; Thomas Amthor; Guillaume Gilbert; Maria Mora; Sarah Schlaeger; Viola Pongratz; Markus Lauerer; Christian Sorg; Mariya Doneva; Irene Vavasour; Mark Mühlau; Christine Preibisch
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)