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Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS by Chirag M Vyas; JoAnn E Manson; Howard D Sesso; Nancy R Cook; Pamela M Rist; Alison Weinberg; M Vinayaga Moorthy; Laura D Baker; Mark A Espeland; Lok-Kin Yeung; Adam M Brickman; Olivia I Okereke is a Medicine article available to read on EtoBox.

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Background: Longer effects of multivitamin-mineral (MVM) supplementation on late-life cognitive function remain untested using in-person, detailed neuropsychological assessments. Furthermore, insufficient evidence exists for healthcare providers to recommend daily MVM supplements to prevent cognitive decline. ## Objectives: To: 1) test MVM effects on cognitive change using in-person, detailed neuropsychological assessments; 2) conduct a meta-analysis within COSMOS (COcoa Supplement and Multivitamin Outcomes Study) cognitive sub-studies for a robust evaluation of MVM effects on cognition. Design: COSMOS is a 2x2 factorial trial of cocoa extract [500 mg flavanols/day] and/or a daily multivitamin-mineral supplement for cardiovascular disease and cancer prevention among 21,442 US adults aged ≥60 years. There were 573 participants in the clinic sub-cohort of COSMOS (i.e., COSMOS-Clinic) who completed all cognitive tests administered at baseline. For meta-analysis, we included non-overlapping participants across three COSMOS cognitive sub-studies: COSMOS-Clinic (n=573); COSMOS-Mind (n=2158); COSMOS-Web (n=2472). ## Results: In COSMOS-Clinic, we observed a modest benefit of MVM, compared

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Author

Chirag M Vyas; JoAnn E Manson; Howard D Sesso; Nancy R Cook; Pamela M Rist; Alison Weinberg; M Vinayaga Moorthy; Laura D Baker; Mark A Espeland; Lok-Kin Yeung; Adam M Brickman; Olivia I Okereke

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Medicine (Health Sciences)