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What is YAP/TAZ Induces Tissue-Specific Stem Cells about?

The study shows that transient expression of the Hippo pathway effectors YAP or TAZ in differentiated mouse cells can induce their conversion to tissue-specific stem/progenitor cells. Specifically, differentiated mammary gland, neuronal, and pancreatic exocrine cells were reprogrammed to proliferating cells displaying properties of stem/progenitor cells of their respective tissues after YAP induction. YAP-induced mammary stem/progenitor cells showed molecular and functional properties similar to endogenous

Author

rufus991

Language

EN