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The Role of Glutamate Transporter‐1a in the Induction of Brain Ischemic Tolerance in Rats by Yi‐Xian Liu; Min Zhang; Li‐Zhe Liu; Xin Cui; Yu‐Yan Hu; Wen‐Bin Li is a Neuroscience article available to read on EtoBox.

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## Abstract This study was undertaken to determine the role of glutamate transporter‐1a (GLT‐1a), one of the splice variants of glutamate transporter‐1, in the induction of brain ischemic tolerance by cerebral ischemic preconditioning (CIP). We used a rat global cerebral ischemic model and assessed changes by neuropathological evaluation, Western blot analysis, immunohistochemistry, real‐time PCR, __in vivo__ brain microdialysis, and high performance liquid chromatography. We found that CIP induced a significant upregulation of GLT‐1a expression in the CA1 hippocampus in a time course corresponding to that of neuroprotection of CIP against brain ischemia. Severe brain ischemia for 8 min induced delayed downregulation of GLT‐1a, an obvious increase in glutamate concentration and delayed neuronal death of the pyramidal neurons in the CA1 hippocampus. When the animals were pretreated with CIP before the severe ischemia, the above changes normally induced by the severe ischemia were effectively prevented. Importantly, such a preventive effect of CIP on these changes was significantly inhibited by intracerebroventricular administration of GLT‐1a antisense oligodeoxynucleotides, which ha

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Author

Yi‐Xian Liu; Min Zhang; Li‐Zhe Liu; Xin Cui; Yu‐Yan Hu; Wen‐Bin Li

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)