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Line Scan Diffusion Spectrum of the Denervated Rat Skeletal Muscle by Eiko Yamabe; Toshiyasu Nakamura; Koichi Oshio; Yoshito Kikuchi; Yoshiaki Toyama; Hiroyasu Ikegami is a Medicine article available to read on EtoBox.

What is Line Scan Diffusion Spectrum of the Denervated Rat Skeletal Muscle about?

## Abstract ## Purpose To detect the earlier changes of the skeletal muscle of rats after peripheral nerve injury by measuring the apparent diffusion coefficient (ADC) on diffusion MR spectroscopy. ## Materials and Methods The posterior tibial nerve was transected in six rats (nerve transection group) and was only dissected in six rats (control group). At one, three, five, seven, 14, and 28 days after the surgery, both the T2 value and the ADC of gastrocnemius muscle were measured using a line‐scan diffusion spectrum on a 1.5T clinical MR imager on both groups. ## Results In the nerve transection group, the T2 ratio compared to the contralateral side increased gradually over four weeks after the transection, while the ADC ratio increased right after the surgery and began to decrease at five days. Four weeks after the transection, the ADC ratio returned to normal while the T2 ratio stayed at a high value. The control group indicated an almost constant T2 and ADC ratio during the experimental periods. ## Conclusion The ADC of the skeletal muscle increased quickly after the transection of the dominant peripheral nerve and was detectable one day after the surgery. Diffusion MRI can be

Who reads Line Scan Diffusion Spectrum of the Denervated Rat Skeletal Muscle?

Author

Eiko Yamabe; Toshiyasu Nakamura; Koichi Oshio; Yoshito Kikuchi; Yoshiaki Toyama; Hiroyasu Ikegami

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2007

Language

EN

Field

Medicine (Health Sciences)