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Inhibition of Influenza Virus Replication by Cocaine by K Grattendick; D.L Lefkowitz; S.S Lefkowitz is a Immunology and Microbiology article available to read on EtoBox.

What is Inhibition of Influenza Virus Replication by Cocaine about?

Cocaine has been shown to have a number of diverse eects on the immune system. The current investigators have previously demonstrated an inhibitory eect of cocaine on murine hepatitis virus replication in peritoneal macrophages in vitro. The present study was undertaken to examine the eects of cocaine on in ̄uenza virus replication and to further characterize that eect in an animal model. Cocaine was capable of inducing a dosedependent reduction in in ̄uenza PR-8 replication using MDCK cells in vitro. Concentrations of 100 mg/ml caused a 50% reduction of virus. To further characterize the eect in vivo, C57Bl/6 mice infected with in ̄uenza PR-8 by intranasal instillation were given daily ip injections of 10 mg/kg cocaine just prior to and for 4 days after exposure to in ̄uenza. Lungs from mice exposed to cocaine had viral titers that were reduced approximately 50% compared to controls as demonstrated by hemagglutination titers.

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Author

K Grattendick; D.L Lefkowitz; S.S Lefkowitz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0192-0561)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)