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Total Synthesis Of Indole Alkaloids: Based On Direct Construction Of Pyrrolocarbazole Scaffolds Via Gold-catalyzed Cascade Cyclizations (springer Theses) by Junpei Matsuoka is a nonfiction available to read on EtoBox.
What is Total Synthesis Of Indole Alkaloids: Based On Direct Construction Of Pyrrolocarbazole Scaffolds Via Gold-catalyzed Cascade Cyclizations (springer Theses) about?
This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compound
Who reads Total Synthesis Of Indole Alkaloids: Based On Direct Construction Of Pyrrolocarbazole Scaffolds Via Gold-catalyzed Cascade Cyclizations (springer Theses)?
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Common subject areas: history, science, philosophy, social sciences.
- Author
- Junpei Matsuoka
- Publisher
- Springer Nature Singapore Pte Ltd Fka Springer Science + Business Media Singapore Pte Ltd
- Published
- 2020
- Language
- EN
- ISBN
- 9789811586538
- Category
- nonfiction
- Subjects
- Science, Chemistry, Medical
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