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Semaglutide Attenuates Excessive Exercise-induced Myocardial Injury Through Inhibiting Oxidative Stress and Inflammation in Rats by Li, Qiang; Tuo, Xinling; Li, Biyou; Deng, Zhijian; Qiu, Yonghong; Xie, Hezhi is a Neuroscience article available to read on EtoBox.
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## Aims: To investigate the protective effects and mechanism of semaglutide on exercise-induced myocardial injury. ## Main methods: Effects of semaglutide on lipopolysaccharide (lps)-induced oxidative stress injuries and inflammatory response were assessed in h9c2 cell via mtt assay and western blot. quiet control group, over training group and three doses of semaglutide treated overtraining groups were subjected to the swimming training with increasing load for consecutive 10 weeks. immediately after the last training, the body weight, myocardial morphological changes, injury markers and inflammatory response related proteins of the model rats were analyzed. ## Key findings: Semaglutide at three concentrations in lps treated h9c2 cells significantly increased the survival rate and inhibited the apoptosis of cardiomyocytes. moreover, semaglutide activated ampk pathway, improve autophagy and inhibited reactive oxygen species production in lps treated h9c2 cells. in vivo results further revealed that chronic treatment of semaglutide induced significant increase in myocardial injury markers. the pathological histology analysis results showed that semaglutide ameliorated myocardial mor
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It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Li, Qiang; Tuo, Xinling; Li, Biyou; Deng, Zhijian; Qiu, Yonghong; Xie, Hezhi
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0024-3205)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)
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