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Can I read Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis on EtoBox?
Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis by Flora Magno de Jesus Oliveira; Cassiano Felippe Gonçalves-de-Albuquerque; Isabel Matos Medeiros de Moraes; Patrícia Alves Reis; Vinicius Novaes Rocha; Patrícia Torres Bozza; Adriana Ribeiro Silva; Hugo Caire de Castro Faria Neto is a Immunology and Microbiology article available to read on EtoBox.
What is Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis about?
Sepsis is characterized by a life-threatening organ dysfunction caused by an unbalanced host response to microbe infection that can lead to death. Besides being currently the leading cause of death in intensive care units worldwide, sepsis can also induce long-term consequences among survivors, such as cognitive impairment. Statins (lipid-lowering drugs widely used to treat dyslipidemia) have been shown to possess pleiotropic anti-inflammatory and antimicrobial effects. These drugs act inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme that catalyzes the conversion of HMG-CoA to mevalonate, the limiting step in cholesterol biosynthesis. In this work, we evaluated the therapeutic effects of simvastatin in an animal model of sepsis. In previous study from our group, statin pretreatment avoided cognitive damage and neuroinflammation in sepsis survivors. Herein, we focused on acute inflammation where sepsis was induced by cecal ligation and puncture (CLP), and the animals were treated with simvastatin (2 mg/kg) 6 h after surgery. We measured plasma biochemical markers of organ dysfunction, cell migration, cell activation, bacterial elimination, production o
Who reads Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Flora Magno de Jesus Oliveira; Cassiano Felippe Gonçalves-de-Albuquerque; Isabel Matos Medeiros de Moraes; Patrícia Alves Reis; Vinicius Novaes Rocha; Patrícia Torres Bozza; Adriana Ribeiro Silva; Hugo Caire de Castro Faria Neto
- Publisher
- Hindawi Publishing Corporation; Hindawi Limited; Abingdon: Carfax; [Cairo]: Hindawi Pub. Corp.; London: Hindawi (ISSN 0962-9351)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)