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Proliferation of prostate cancer cells and activity of neutral endopeptidase is regulated by bombesin and IL-1β with IL-1β acting as a modulator of cellular differentiation by Martin Albrecht; Jolanta Doroszewicz; Sonja Gillen; Iara Gomes; Beate Wilhelm; Thomas Stief; Gerhard Aumüller is a Medicine article available to read on EtoBox.
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## Abstract ## BACKGROUND Neutral endopeptidase (NEP) is a cell‐surface bound enzyme that cleaves and inactivates neuropeptides such as bombesin and substance P and is involved in the transition from hormonally regulated androgen‐dependent prostate cancer (PC) to androgen‐independent PC. Neuropeptides are implicated in growth regulation of different cell types and function as transmitters between the neuroendocrine and the immune system. ## METHODS NEP‐expression, enzymatic activity of the membrane bound protein, cell proliferation, procalcitonin (PCT) production, and secretion as well as changes in cell morphology of prostatic cells were evaluated after treatment with the immunomodulatory cytokine interleukin‐1β (IL‐1β), neuropeptides (bombesin, substance P), and neuropeptide‐conditioned media derived from a human neuroendocrine cell line. ## RESULTS Incubation of LNCaP tumor cells with IL‐1β resulted in a diminished proliferative activity, induction of neurite‐like outgrowth which was accompanied by the formation of tubular‐type mitochondria typical for neuronal/neuroendocrine cells, and an increased production and secretion of PCT. Conversely, proliferation of prostatic stromal
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- Author
- Martin Albrecht; Jolanta Doroszewicz; Sonja Gillen; Iara Gomes; Beate Wilhelm; Thomas Stief; Gerhard Aumüller
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)