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195. Predicting Patients With Dementia Most at Risk of Needing Psychiatric Inpatient or Enhanced Community Care Using Routinely Collected Clinical Data by Sabina London; Shanquan Chen; Emad Sidhom; Jonathan Lewis; Rudolf Cardinal; David Roalf; Benjamin Underwood is a Neuroscience article available to read on EtoBox.

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with FAAH inhibitor, PF-3845. We then used the BDNFMet/ MetFAAHA/A double knock-in mice to see the possible synergistic effects of the two SNPs. Two or three-way ANOVAs were used for statistical analyses.Results: Unlike WT littermate controls (n1⁄410) that generalized fear responses to the strong shock condition, FAAH C385A mice (n1⁄411) showed increased fear discrimination after strong shock (p<0.001) with improved cued fear extinction (p<0.001). WT mice injected with PF-3845 (n1⁄410) showed enhanced fear discrimination and extinction compared to controls (n1⁄49, p<0.001). We then showed that BDNFMet/MetFAAHA/A double knock-in mice showed a diminished anxiety-related phenotype compared to BDNFMet/Met mice (n1⁄417 per group, p<0.01).Conclusions: Overall, we demonstrate the interplay of the endocannabinoid and neurotrophic system in fear generalization and anxiety-like behaviors in mice, with potential implications for refined treatment of mood and anxiety-based disorders.

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Author

Sabina London; Shanquan Chen; Emad Sidhom; Jonathan Lewis; Rudolf Cardinal; David Roalf; Benjamin Underwood

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)