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pH-Responsive chitosan-modified gadolinium oxide nanoparticles delivering 5-aminolevulinic acid: A dual cellular and metabolic T1-T2* contrast agent for glioblastoma brain tumors detection by Elham Gholibegloo; Anita Ebrahimpour; Tohid Mortezazadeh; Farzaneh Sorouri; Alireza Foroumadi; Loghman Firoozpour; Mehdi Shafiee Ardestani; Mehdi Khoobi is a Chemical Engineering article available to read on EtoBox.

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Diagnosis of glioblastoma multiforme (GBM) with high sensitivity and specificity requires cellular and metabolic imaging. In this study, we aimed to endow gadolinium oxide nanoparticles (Gd2O3 NPs) as an interesting T1 contrast agent with T2* contrast ability through intracellular iron assistance induced by 5-aminolevulinic acid (5-ALA) with ferric ammonium citrate (FAC). Chitosan (CS)-loaded Gd2O3 NPs were loaded with 5-aminolevulinic acid (Gd2O3/CS-TPP@5-ALA NPs), and then evaluated as a pH-responsive dual cellular and metabolic T1 and T2* contrast agent for GBM diagnosis. The target NPs with an average size of 138 nm revealed concentration-dependent toxicity against glioblastoma C6 cells. The relaxation rate (R1) of the C6 cells treated with Gd2O3/CS-TPP@5-ALA NPs plus FAC was remarkably higher than the controls including Gd2O3/CS-TPP NPs, Gd2O3/CS-TPP@5-ALA NPs, and FAC (17.2 ± 2.4 vs. 8 ± 1.5, 8.4 ± 1.2, and 2.3 ± 0.5, respectively). Interestingly, the transverse relaxation rate (R2*) of the C6 cells treated with Gd2O3/CS-TPP@5-ALA NPs + FAC was significantly higher than the controls including Gd2O3/CS-TPP NPs, Gd2O3/CS-TPP@5-ALA NPs, and FAC (96 ± 8 vs. 25 ± 4, 27 ± 5, and 19

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Author

Elham Gholibegloo; Anita Ebrahimpour; Tohid Mortezazadeh; Farzaneh Sorouri; Alireza Foroumadi; Loghman Firoozpour; Mehdi Shafiee Ardestani; Mehdi Khoobi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Chemical Engineering (Physical Sciences)