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Can I read Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death on EtoBox?
Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death by Henrik H. Hansen; Chrysanthy Ikonomidou; Petra Bittigau; Steen Honoré Hansen; Harald S. Hansen is a Neuroscience article available to read on EtoBox.
What is Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death about?
It has been demonstrated that the endogenous cannabinoid receptor ligand, anandamide, and other __N__‐acylethanolamines (NAEs), accumulate during neuronal injury __in vitro__, a process that may be linked to the neuroprotective effects of NAEs. The crucial step for generation of NAEs is the synthesis of the corresponding precursors, __N__‐acylethanolamine phospholipids (NAPEs). However, it is unknown whether this key event for NAE formation is regulated differently in the context of insults causing necrotic or apoptotic neuronal death. To address this question, we monitored a range of cortical NAPE species in three infant rat models of __in vivo__ neurodegeneration: (i) necrosis caused by intrastriatal injection of NMDA (25 nmol); (ii) apoptosis induced by systemic administration of the NMDA‐receptor antagonist (+)MK‐801 (3 × 0.5 mg/kg, i.p.); and (iii) apoptosis following focal necrosis triggered by concussive head trauma. A marked increase of all NAPE species was observed in both hemispheres 4 and 24 h after NMDA‐induced injury, with a relatively larger increase in __N__‐stearoyl‐containing NAPE species. Thus, the percentage of the anandamide precursor fell from 1.1 to 0.5 mol %.
Who reads Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Henrik H. Hansen; Chrysanthy Ikonomidou; Petra Bittigau; Steen Honoré Hansen; Harald S. Hansen
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)