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Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis by Debra M. Butler; Anne-Marie Malfait; Ravinder N. Maini; Fionula M. Brennan; Marc Feldmann is a Immunology and Microbiology article available to read on EtoBox.

What is Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis about?

The co-ordinate role of the Th1 cytokine IL-12 and the proinflammatory cytokine TNF in arthritis was explored using the DBA/1 mouse model, collagen-induced arthritis (CIA). In this study, mice with established arthritis were treated with anti-IL-12 and/or anti-TNF antibodies for 10 days from the onset of disease. Clinical assessment showed that the combined antibody treatment ameliorated disease severity to a greater extent than anti-TNF alone. Supporting these observations, histological analysis revealed that there was a reduced joint damage in the mice that received combined anti-IL-12 and anti-TNF treatment, compared to the other treatment groups. Anti-IL-12 had no statistically significant effect on the clinical outcome of disease. The combination of anti-IL-12 and anti-TNF treatment was found to reduce collagen type II (CII)-specific lymph node cell IFN-+ production and proliferation, as well as decrease the anti-CII IgG2a : IgG1 ratio more effectively than either treatment alone. When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro, anti-TNF diminished IL-12 production, but anti-IL-12 had no effect on TNF production. These

Who reads Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis?

Author

Debra M. Butler; Anne-Marie Malfait; Ravinder N. Maini; Fionula M. Brennan; Marc Feldmann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)