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Significance of Myelofibrosis in Early Chronic-phase, Chronic Myelogenous Leukemia on Imatinib Mesylate Therapy by Hagop M. Kantarjian; Carlos E. Bueso-Ramos; Moshe Talpaz; Susan O'Brien; Francis Giles; Stefan Faderl; William Wierda; Mary Beth Rios; Jianqin Shan; Jorge Cortes is a Medicine article available to read on EtoBox.
What is Significance of Myelofibrosis in Early Chronic-phase, Chronic Myelogenous Leukemia on Imatinib Mesylate Therapy about?
## Abstract ## BACKGROUND Myelofibrosis is associated historically with a poor prognosis in patients with chronic myelogenous leukemia (CML). Its significance in the recent era of effective therapy with imatinib mesylate is unknown. ## METHODS The current study evaluated the significance of the degree of pretreatment myelofibrosis on response and survival with imatinib therapy in patients with newly diagnosed CML. The study group comprised 198 patients with newly diagnosed Philadelphia chromosome‐positive, chronic‐phase CML treated with imatinib mesylate therapy. They were analyzed for the prognostic significance of bone marrow reticulin fibrosis. ## RESULTS Severe reticulin (Grade 3–4) fibrosis was observed in 75 patients (38%): Grade 3 in 46 (23%) patients and Grade 4 in 29 (15%) patients. There was a trend towards a lower incidence of a complete cytogenetic response in patients with Grade 4 reticulin fibrosis (76% vs. 89%; __P__ = 0.07), and a significantly worse survival (estimated 3‐year survival rate of 87% vs. 97%; __P__ = 0.04). ## CONCLUSIONS Although the prognostic significance of severe reticulin fibrosis in patients with newly diagnosed CML receiving imatinib therapy wa
Who reads Significance of Myelofibrosis in Early Chronic-phase, Chronic Myelogenous Leukemia on Imatinib Mesylate Therapy?
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- Author
- Hagop M. Kantarjian; Carlos E. Bueso-Ramos; Moshe Talpaz; Susan O'Brien; Francis Giles; Stefan Faderl; William Wierda; Mary Beth Rios; Jianqin Shan; Jorge Cortes
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)