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Mechanisms of alterations in cardiac membrane Ca2+ transport due to excess catecholamines by Ken S. Dhalla; Heinz Rupp; Robert E. Beamish; Naranjan S. Dhalla is a Medicine article available to read on EtoBox.

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The occurrence of excessive catecholamine release is often associated with stress due to the lifestyle of Western societies. Contrary to the general thinking that excess catecholamines produce cardiotoxicity mainly via binding to adrenoceptors, there is increasing evidence that catecholamine-induced deleterious actions may also occur through oxidative mechanisms. In this overview it is shown that a high dose of isoproterenol induces a biphasic change in cardiac Ca2+ transport in the sarcolemma and in sarcoplasmic reticulum. Both sarcolemmal and sarcoplasmic reticular Ca2+-transport activities are initially increased to maintain Ca2+ homeostasis and then are impaired, which may be associated with the occurrence of intracellular Ca2+ overload. On the other hand, mitochondrial Ca2+-transport activities exhibited a delayed increase. Pretreatment with vitamin E partially prevented the deleterious changes in cardiac membranes as well as the depressed energetic status of the heart muscle cell. It is concluded that excess catecholamines affect Ca2+-transport mechanisms primarily via oxidation reactions involving free radical-mediated damage. Thus drug approaches that reduce circulating cat

Who reads Mechanisms of alterations in cardiac membrane Ca2+ transport due to excess catecholamines?

Author

Ken S. Dhalla; Heinz Rupp; Robert E. Beamish; Naranjan S. Dhalla

Publisher

Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0920-3206)

Published

1996

Language

EN

Field

Medicine (Health Sciences)