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Melatonin: Receptor-mediated events that may affect breast and other steroid hormone–dependent cancers by William S. Baldwin; J. Carl Barrett is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Melatonin: Receptor-mediated events that may affect breast and other steroid hormone–dependent cancers about?

Epidemiological studies have suggested a possible link between extremely low frequency electromagnetic fields (EMFs) and increased rates of certain cancers. One cancer that has been postulated to be associated with EMF exposure is breast cancer, for which increased rates have been reported among electricians. These cancer associations are weak, and the link to EMF exposures remains tenuous. Understanding the mechanisms by which EMFs could have biological effects will help in elucidating the risk, if any, from EMFs. One hypothesis that has received considerable attention involves reduction of melatonin levels by EMFs. This hypothesis suggests that loss of melatonin affects a variety of hormonal processes such as estrogen homeostasis and thereby may increase breast cancer rates. Since this theory was first presented, putative melatonin receptors have been cloned, providing new tools with which to examine melatonin's mechanism of action and the melatonin hypothesis. These receptors are found in nuclear and membrane fractions of cells. The nuclear receptors (retinoid Z receptors) are found both in the brain and in non-neural tissues, whereas the membrane-bound receptors are found prima

Who reads Melatonin: Receptor-mediated events that may affect breast and other steroid hormone–dependent cancers?

Author

William S. Baldwin; J. Carl Barrett

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)