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High Cellulose Diet Promotes Intestinal Motility Through Regulating Intestinal Immune Homeostasis and Serotonin Biosynthesis by Tao Xie; Fa Jin; Xiaokun Jia; Hengxu Mao; Yuting Xu; Shizhong Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is High Cellulose Diet Promotes Intestinal Motility Through Regulating Intestinal Immune Homeostasis and Serotonin Biosynthesis about?

It is widely accepted dietary fiber intimately linked to inflammatory and nervous diseases, which often been described with altered gastrointestinal (GI) motility. However, how dose dietary fiber modulate inflammation and crosstalk influence GI function has not been explained in detail. We found fiber-free diet reduced intestinal motility, accompanied by upregulated proinflammatory immunocytes and inflammatory cytokines in colon of mice. We also discovered high-cellulose diet increased synthesis of serotonin and expression of neurotrophic factors, both of that have been reported involved in promoting intestinal motility. In addition, metabolomics analysis showed increased tryptophan metabolites in high-cellulose diet mice, which happened to be required for serotonin biosynthesis. Further analysis revealed high-cellulose diet changed the composition of gut microbiota, in particular by altering the ratio of Firmicutes to Bacteroidetes, consequently, concentration of short-chain fatty acids (SCFAs), especially acetate. Orally administration of acetate confirmed its modulating to serotonin synthesis, neurotrophic factors expression and immunocyte differentiation through regulating hist

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Author

Tao Xie; Fa Jin; Xiaokun Jia; Hengxu Mao; Yuting Xu; Shizhong Zhang

Publisher

Walter de Gruyter GmbH

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)