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Warfarin: an Environment-dependent Switchable Molecular Probe by Ian A. Nicholls; Björn C. G. Karlsson; Annika M. Rosengren; Henning Henschel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Warfarin: an Environment-dependent Switchable Molecular Probe about?

## Abstract The complex nature of the structure of the anticoagulant warfarin is reflected in the diversity of binding modes observed in warfarin–protein recognition systems. A series of theoretical, ^1^H‐NMR and steady state and time resolved fluorescence spectroscopic studies, have been used to establish correlations between the molecular environment provided by various solvent systems and the relative concentrations of the various members of warfarin's ensemble of isomers. A consequence of these observations is that the judicious choice of solvent system or molecular environment of warfarin allows for manipulation of the position of the equilibrium between isomeric structures such as the hemiacetal and open phenol‐keto forms, the latter even possible in a deprotonated form, where in each case unique spectroscopic properties are exhibited by the respective structures. Collectively, warfarin's capacity to adapt its structure as a function of environment in conjunction with the fluorescence behaviours of the various isomers together provide an environment‐dependent molecular switch with reporter properties, which allows for the simultaneous detection of warfarin in different states

Who reads Warfarin: an Environment-dependent Switchable Molecular Probe?

Author

Ian A. Nicholls; Björn C. G. Karlsson; Annika M. Rosengren; Henning Henschel

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3499)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)