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Can I read Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development on EtoBox?
Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development by Ryoichi Hosokawa; Xuemei Deng; Kazunori Takamori; Xun Xu; Mark Urata; Pablo Bringas Jr; Yang Chai is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development about?
## Abstract Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial–mesenchymal tissue interaction. We have generated epithelial‐specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (__Fgfr2__) to investigate the function of FGF signaling during craniofacial development. __K14‐Cre;Fgfr2^fl/fl^__ mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of __K14‐Cre;Fgfr2^fl/fl^__ mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development. __J. Exp. Zool. (Mol. Dev. Evol.) 312B:343–350, 2009__. © 2009 Wiley‐Liss, Inc.
Who reads Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ryoichi Hosokawa; Xuemei Deng; Kazunori Takamori; Xun Xu; Mark Urata; Pablo Bringas Jr; Yang Chai
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1552-5007)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)