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Can I read Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines on EtoBox?
Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines by Jing Li; Ji Zhang; Qiao-Sen Lu; Yang Yue; Yu Huang; Da-Wei Zhang; Hong-Hui Lin; Shan-Yong Chen; Xiao-Qi Yu is a Chemistry article available to read on EtoBox.
What is Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines about?
Novel bis-cyclen derivative A with urea, mono-cyclen derivative B with urea and amino acid urea C were synthesized as DNA cleavage agents. The structures of these new compounds were identified by MS and 1 H NMR spectroscopy. The catalytic activities on DNA cleavage of these compounds were subsequently studied, and results show that A is a much better catalyst in DNA cleavage process than that of B and C. The effects of reaction time and catalyst concentration were also investigated. The results indicate that A can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) to nicked DNA under physiological conditions with high yields (nearly 100%) via a hydrolytic mechanism.
Who reads Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jing Li; Ji Zhang; Qiao-Sen Lu; Yang Yue; Yu Huang; Da-Wei Zhang; Hong-Hui Lin; Shan-Yong Chen; Xiao-Qi Yu
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)