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Synthesis of New 1,1-Dimethyl-1,2,3,4-tetrahydrophenanthrene Derivatives by Xian-Zhang Bu; Zhi-Shu Huang; Min Zhang; Lin Ma; Gui-Wu Xiao; Lian-Quan Gu is a Chemistry article available to read on EtoBox.

What is Synthesis of New 1,1-Dimethyl-1,2,3,4-tetrahydrophenanthrene Derivatives about?

Naturally occurring diterpenoid tanshinones have attracted particular attention from medicinal chemists and clinicians because many of them exhibit interesting physiological properties. 1 Cryptotanshinone 1, a typical diterpenoid tanshinone from Salvia miltiorrhiza Bunge, was found to exhibit enzyme inhibitory activities. 2 Tanshinone 1 is characterised by the presence of a dihydrofuran ring and an o-quinone moiety, which are able to react with nucleophilic agents. In this paper, we report the interaction of cryptotanshinone with NH 3 , CH 3 NH 2 and C 2 H 5 NH 2 (Scheme 1), which may afford more direct evidence for the mechanism of the inhibitory activity of tanshinones with various enzymes.

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Author

Xian-Zhang Bu; Zhi-Shu Huang; Min Zhang; Lin Ma; Gui-Wu Xiao; Lian-Quan Gu

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

2001

Language

EN

Field

Chemistry (Physical Sciences)