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Tregs Biomimetic Nanoparticle to Reprogram Inflammatory and Redox Microenvironment in Infarct Tissue to Treat Myocardial Ischemia Reperfusion Injury in Mice by Fangyuan Li; Daozhou Liu; Miao Liu; Qifeng Ji; Bangle Zhang; Qibing Mei; Ying Cheng; Siyuan Zhou is a Engineering article available to read on EtoBox.
What is Tregs Biomimetic Nanoparticle to Reprogram Inflammatory and Redox Microenvironment in Infarct Tissue to Treat Myocardial Ischemia Reperfusion Injury in Mice about?
## Background At present, patients with myocardial infarction remain an increased risk for myocardial ischemia/reperfusion injury (MI/RI). There lacks effectively method to treat MI/RI in clinic. For the treatment of MI/RI, it is still a bottleneck to effectively deliver drug to ischemic myocardium. In this paper, a regulatory T cells (Tregs) biomimetic nanoparticle (CsA@PPTK) was prepared by camouflaging nanoparticle with platelet membrane. ## Results CsA@PPTK actively accumulated in ischemic myocardium of MI/RI mice. CsA@PPTK significantly scavenged reactive oxygen species (ROS) and increased the generation of Tregs and the ratio of M2 type macrophage to M1 type macrophage in ischemic myocardium. Moreover, CsA@PPTK significantly attenuated apoptosis of cardiomyocytes and reduced the infarct size and fibrosis area in ischemic myocardium. CsA@PPTK markedly decreased the protein expression of MMP-9 and increased the protein expression of CX43 in ischemic myocardium tissue. Subsequently, the remodeling of the left ventricle was significant alleviated, and heart function of MI/RI mice was markedly improved. ## Conclusion CsA@PPTK showed significant therapeutic effect on MI/RI, and it
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- Author
- Fangyuan Li; Daozhou Liu; Miao Liu; Qifeng Ji; Bangle Zhang; Qibing Mei; Ying Cheng; Siyuan Zhou
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)