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What is Bio-Targets and Drug Delivery Approaches about?

1 1 Half Title 1 Title Page 3 Copyright Page 4 Table of Contents 5 Preface 9 Contributors 11 2 15 Chapter 1: Basic Concepts in Drug Targeting 15 1.1 Introduction 15 1.2 Classification of Targeted DDSs 18 1.3 Approaches Involved in Drug Targeting 18 1.3.1 Inverse Targeting Strategy 20 1.3.2 Dual Targeting Strategy 21 1.3.3 Double Targeting Strategy 21 1.3.4 Combination Targeting Strategy 21 1.4 Endocytic Pathways for Targeted Delivery to Enter Cells 22 1.4.1 Phagocytosis 24 1.4.2 Pinocytosis 25 1.4.2.1 Clathrin-Dependent Endocytosis 25 1.4.2.2 Caveolae-Dependent Endocytosis 27 1.4.2.3 Macropinocytosis 29 1.4.2.4 Clathrin- and Caveolae-Independent Endocytosis 31 1.5 Modeling of PK and Pharmacodynamics 32 1.6 Regulatory Considerations 34 References 37 3 47 Chapter 2: Biological Targets: Identification, Selection, and Validation 47 2.1 Introduction 47 2.2 Evolution of Drug Discovery: Serendipity to Rationality 49 2.3 Biological Targets: Impact on Drug Discovery and Pharmaceutical Industries 50 2.4 Approaches to Target Identification and Selection 52 2.4.1 Direct Biochemical Methods 53 2.4.2 Genetic Interaction and Genomic Methods 54 2.4.3 Computational Inference Methods 54 2.5 Dynamics

Author

Sabyasachi Maiti and Kalyan Kumar Sen

Publisher

CRC Press LLC

Published

2017

Language

EN

ISBN

9781315353074

Subjects

Medical, Science, Chemistry