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Revisiting Mouse Minute Virus Inactivation by High Temperature Short Time Treatment by Joleen Su; Jonathan Rice; Jacob Hoffman; Shelley Alvarado; Mark Bailey; Martina Kopp; Marie Murphy; Robert Kiss; Paul W. Barone; Michael E. Wiebe; Stacy L. Springs; Houman Dehghani; Dayue Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Revisiting Mouse Minute Virus Inactivation by High Temperature Short Time Treatment about?
## Abstract In recent years, high temperature short time (HTST) treatment technology has been increasingly adopted for medium treatment to mitigate the potential risk of viral contamination in mammalian cell culture GMP manufacturing facilities. Mouse minute virus (MMV), also called minute virus of mice (MVM), implicated in multiple viral contamination events is commonly used as a relevant model virus to assess the effectiveness of HTST treatment of cell culture media. However, results from different studies vary broadly in inactivation kinetics as well as log reduction factors (LRFs) achieved under given treatment conditions. To determine whether the reported discrepancies stemmed from differences in MMV strains, laboratory‐scale HTST devices, medium matrices, and/or experimental designs, we have taken a collaborative approach to systematically assess the effectiveness of HTST treatment for MMV inactivation. This effort was conceptualized based on a media treatment gap analysis conducted by the Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB) under the MIT Center for Biomedical Innovation (CBI). Specifically, two different MMV strains were used to evaluat
Who reads Revisiting Mouse Minute Virus Inactivation by High Temperature Short Time Treatment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Joleen Su; Jonathan Rice; Jacob Hoffman; Shelley Alvarado; Mark Bailey; Martina Kopp; Marie Murphy; Robert Kiss; Paul W. Barone; Michael E. Wiebe; Stacy L. Springs; Houman Dehghani; Dayue Chen
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)