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Delayed Neurotrophic Treatment Preserves Nerve Survival and Electrophysiological Responsiveness in Neomycin‐deafened Guinea Pigs by Takahiko Yamagata; Josef M. Miller; Mats Ulfendahl; N. Petri Olivius; Richard A. Altschuler; Ilmari Pyykkö; Göran Bredberg is a Neuroscience article available to read on EtoBox.
What is Delayed Neurotrophic Treatment Preserves Nerve Survival and Electrophysiological Responsiveness in Neomycin‐deafened Guinea Pigs about?
## Abstract Benefits of cochlear prostheses for the deaf are dependent on survival and excitability of the auditory nerve. Degeneration of deafferented auditory nerve fibers is prevented and excitability maintained by immediate replacement therapy with exogenous neurotrophic factors, in vivo. It is important to know whether such interventions are effective after a delay following deafness, typical for the human situation. This study evaluated the efficacy of brain‐derived neurotrophic factor (BDNF) and ciliary neurotrophic factor axokine‐1 analogue (CNTF~Ax1~) application, 2 or 6 weeks postdeafening, in preventing further degeneration and a decrease in excitability. Guinea pigs were deafened and implanted with intracochlear stimulating electrodes, a scala tympani cannula‐osmotic pump system, and auditory brainstem response (ABR) recording electrodes. Subjects received BDNF + CNTF~Ax1~ or artificial perilymph (AP) treatment for 27 days, beginning at 2 or 6 weeks following deafening. Electrical (E) ABR thresholds increased following deafening. After 1 week, in the 2‐weeks‐delayed neurotrophic factor treatment group, EABR thresholds decreased relative to AP controls, which were statis
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- Author
- Takahiko Yamagata; Josef M. Miller; Mats Ulfendahl; N. Petri Olivius; Richard A. Altschuler; Ilmari Pyykkö; Göran Bredberg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2004
- Language
- EN
- Field
- Neuroscience (Life Sciences)