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Effects of collagen membranes enriched with in vitro-differentiated N1E-115 cells on rat sciatic nerve regeneration after end-to-end repair by Sandra Amado; Jorge M Rodrigues; Ana L Luís; Paulo AS Armada-da-Silva; Márcia Vieira; Andrea Gartner; Maria J Simões; António P Veloso; Michele Fornaro; Stefania Raimondo; Artur SP Varejão; Stefano Geuna; Ana C Maurício is a Medicine article available to read on EtoBox.

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## Abstract Peripheral nerves possess the capacity of self-regeneration after traumatic injury but the extent of regeneration is often poor and may benefit from exogenous factors that enhance growth. The use of cellular systems is a rational approach for delivering neurotrophic factors at the nerve lesion site, and in the present study we investigated the effects of enwrapping the site of end-to-end rat sciatic nerve repair with an equine type III collagen membrane enriched or not with N1E-115 pre-differentiated neural cells. After neurotmesis, the sciatic nerve was repaired by end-to-end suture (__End-to-End__ group), end-to-end suture enwrapped with an equine collagen type III membrane (__End-to-EndMemb__ group); and end-to-end suture enwrapped with an equine collagen type III membrane previously covered with neural cells pre-differentiated __in vitro__ from N1E-115 cells (__End-to-EndMembCell__ group). Along the postoperative, motor and sensory functional recovery was evaluated using extensor postural thrust (EPT), withdrawal reflex latency (WRL) and ankle kinematics. After 20 weeks animals were sacrificed and the repaired sciatic nerves were processed for histological and stere

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Author

Sandra Amado; Jorge M Rodrigues; Ana L Luís; Paulo AS Armada-da-Silva; Márcia Vieira; Andrea Gartner; Maria J Simões; António P Veloso; Michele Fornaro; Stefania Raimondo; Artur SP Varejão; Stefano Geuna; Ana C Maurício

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1743-0003)

Published

2010

Language

EN

Field

Medicine (Health Sciences)