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Endogenous sex hormones and the risk of prostate cancer: A prospective study by Jocelyn M. Weiss; Wen‐Yi Huang; Sabina Rinaldi; Thomas R. Fears; Nilanjan Chatterjee; Ann W. Hsing; E. David Crawford; Gerald L. Andriole; Rudolf Kaaks; Richard B. Hayes is a Medicine article available to read on EtoBox.

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## Abstract Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in epidemiologic studies. We conducted a nested case‐control study with prospectively collected samples in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, to examine associations of prostate cancer with androstenedione (Δ4‐A), testosterone (T), sex hormone‐binding globulin (SHBG) and 3α‐androstanediol glucuronide (3α‐diolG). A total of 727 incident Caucasian prostate cancer cases (age ≥ 65 years, __N__ = 396) and 889 matched controls were selected for this analysis. Overall, prostate cancer risks were unrelated to serum T, estimated free and bioavailable T, and SHBG; however, risks increased with increasing T:SHBG ratio (__p__~trend~ = 0.01), mostly related to risk in older men (≥65 years, __p__~trend~ = 0.001), particularly for aggressive disease [highest __versus__ lowest quartile: odds ratio (OR) 2.76, 95% confidence interval (CI) 1

Who reads Endogenous sex hormones and the risk of prostate cancer: A prospective study?

Author

Jocelyn M. Weiss; Wen‐Yi Huang; Sabina Rinaldi; Thomas R. Fears; Nilanjan Chatterjee; Ann W. Hsing; E. David Crawford; Gerald L. Andriole; Rudolf Kaaks; Richard B. Hayes

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2008

Language

EN

Field

Medicine (Health Sciences)