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Can I read Mass spectrometry-based candidate substrate and site identification of PTM enzymes on EtoBox?
Mass spectrometry-based candidate substrate and site identification of PTM enzymes by Weiyu Chen; Guanghui Ji; Roujun Wu; Caiyun Fang; Haojie Lu is a Chemistry article available to read on EtoBox.
What is Mass spectrometry-based candidate substrate and site identification of PTM enzymes about?
Protein post-translational modifications (PTMs), which include covalent addition of functional groups to proteins and removal of specific amino acid(s) from proteins after synthesis, are often regulated by enzymes and linked to various cellular processes. Identification of enzyme substrates and their modification sites can assist in understanding the control of PTM enzymes on cellular processes, which is important for comprehending physiopathological processes. Due to the rapid advancement of analytical techniques, mass spectrometry (MS)-based proteomic approach has been one of the dominant methods for detecting enzyme-substrate interactions and modification site preferences in biological samples. Here, the development and optimization of MS-based proteomic methodologies in profiling substrates of PTM enzymes are briefly reviewed.
Who reads Mass spectrometry-based candidate substrate and site identification of PTM enzymes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Weiyu Chen; Guanghui Ji; Roujun Wu; Caiyun Fang; Haojie Lu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)