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Can I read Amniotic Fluid Microvillar Enzyme Activities in the Early Detection of Fetal Abnormalities on EtoBox?
Amniotic Fluid Microvillar Enzyme Activities in the Early Detection of Fetal Abnormalities by David J. H. Brock; David Bedgood; Caroline Hayward; Neil J. Carbarns; Christine Gosden is a Medicine article available to read on EtoBox.
What is Amniotic Fluid Microvillar Enzyme Activities in the Early Detection of Fetal Abnormalities about?
## Abstract Measurement of the microvillar enzymes, γ‐glutamyltranspeptidase (GGTP), aminopeptidase M (APM) and alkaline phosphatase (ALP), in amniotic fluid supernatant has been proposed as a method for the early prenatal diagnosis of cystic fibrosis. The activities of these enzymes in a series of other fetal abnormalities have now been examined. GGTP activities were below the 5th percentile in 28 out of 54 cases of trisomy 21 and 9 of 14 cases of trisomy 18, while APM values were below this cut‐off in 26 of 54 cases of trisomy 21 and 8 of 14 cases of trisomy 18. Abnormal ALP isoenzyme ratios were found in 6 of 54 cases of trisomy 21 and 4 of 14 cases of trisomy 18. If prenatal cytogenetic studies are routinely carried out on amniotic fluid cells, the occasional confounding effect of abnormal microvillar enzymes associated with fetal trisomies rather than with cystic fibrosis should be avoided.
Who reads Amniotic Fluid Microvillar Enzyme Activities in the Early Detection of Fetal Abnormalities?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- David J. H. Brock; David Bedgood; Caroline Hayward; Neil J. Carbarns; Christine Gosden
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)
- Published
- 1984
- Language
- EN
- Field
- Medicine (Health Sciences)