About this Medicine article
Suspension polymerization of 2-hydroxyethyl methacrylate in the presence of polymeric diluents: A novel route to spherical highly porous beads for biomedical applications by J. Jayakrishnan; B. Chithambara Thanoo is a Medicine article available to read on EtoBox.
Spherical, highly porous beads of poly(2hydroxyethyl methacrylate) (PHEh4A) cross- linked with ethylene glycol dimethacrylate (EGDM) were prepared by suspension polymerization of HEMA in concentrated NaCl solutions in presence of toluene, poly(methy1 methacrylate) (PMMA) in toluene, and poly(tetramethy1ene glycol) (PTMG). Magnesium hydroxide prepared in situ in the dispersion medium gave the best stabilization effect for the monomer droplets. In the presence of PTMG, beads having nearly 1.0 mm in diameter could be prepared, while toluene alone as the diluent produced beads of very small size. Removal of PMMA or PTMG from the beads after polymerization using suitable solvents gave rise to highly porous PHEMA microspsheres. Polymerization in the presence of PTMG produced microspsheres with better spherical geometry as compared to those generated in the presence of PMMA. The effect of various factors such as NaCl concentration, concentration of Mg(OH)\*, and the concentration of PMMA or PTMG in the monomer phase on the stability of the suspension and the particle size distribution was investigated.
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- Author
- J. Jayakrishnan; B. Chithambara Thanoo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)
- Published
- 1990
- Language
- EN
- Field
- Medicine (Health Sciences)