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Effect of Tumor Necrosis Factor-α and Interferon-γ on the Growth of a Human Salivary Gland Cell Line by Ava J. Wu; Regina H. Kurrasch; Joseph Katz; Philip C. Fox; Bruce J. Baum; Jane C. Atkinson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Effect of Tumor Necrosis Factor-α and Interferon-γ on the Growth of a Human Salivary Gland Cell Line about?
## Abstract Interferon‐γ (IFN‐γ) is a product of activated T‐lymphocytes, and tumor necrosis factor‐α (TNF‐α) is a product of both lymphocytes and macrophages. These cell types are often present at sites of tissue damage secondary to chronic infection or autoimmune disease. The purpose of this study was to characterize the effects of TNF‐α and IFN‐γ on a human submandibular gland epithelial cell line (HSG). IFN‐γ caused a concentration‐dependent decrease in HSG cell growth (∼70% in 6 days). Conversely, TNF‐α alone had little effect on the growth of these cells. When these cytokines were added in combination (20 units/ml TNF‐α and 1,000 units/ml of IFN‐γ), there was a synergistic antiproliferative effect; no apparent cell growth was observed. The cytokine‐induced antiproliferative effect was reversible. After the apparent cessation of cell growth for 3–6 days, removal of the cytokines permitted complete growth recovery. Further, cells that recovered and exhibited growth patterns that were similar to control cells remained susceptible to the antiproliferative effects of the cytokines. Flow cytometry revealed that the percentage of cells in G0/G1 with the combination of cytokines was
Who reads Effect of Tumor Necrosis Factor-α and Interferon-γ on the Growth of a Human Salivary Gland Cell Line?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ava J. Wu; Regina H. Kurrasch; Joseph Katz; Philip C. Fox; Bruce J. Baum; Jane C. Atkinson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1994
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)