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Epidemiological associations of allergy, IgE and cancer by D. H. Josephs1,2, J. F. Spicer2, C. J. Corrigan3, H. J. Gould4 and S. N. Karagiannis1 is a book available to read on EtoBox.

What is Epidemiological associations of allergy, IgE and cancer about?

SummarySeveral epidemiological studies have evaluated potential associations between allergy andrisk of malignancy. It remains clear that the relationship between allergy and cancer isExperimentalcomplex. Three hypotheses have been proposed to account for observed relationships:these are chronic inflammation, immunosurveillance, prophylaxis, and we propose addingCorrespondence:Allergya fourth: inappropriate T-helper 2 (Th2) immune skewing. Each of these attempts toexplain either the increased or decreased risk of different cancer types in ‘allergic’ patientsreported in the literature. All four hypotheses are based on known mechanisms of allergicDr Sophia N. Karagiannis and Debrainflammation and/or IgE antibody functions, and uphold the view of an immunologicalH. Josephs, Cutaneous Medicine andbasis for the relationship between allergy and malignancies. This review summarizes andImmunotherapy Unit, St. John’sdraws conclusions from the epidemiological literature examining the relationshipsInstitute of Dermatology, Division ofGenetics and Molecular Medicinebetween specific types of cancer and allergic diseases. Particular emphasis is placed onKing’s College London School ofthe most re

Author

D. H. Josephs1,2, J. F. Spicer2, C. J. Corrigan3, H. J. Gould4 and S. N. Karagiannis1

Published

2013

Language

EN